They’ll likely prescribe a treatment other than hydrochlorothiazide for your condition. Doctors typically will not prescribe hydrochlorothiazide for people with anuria (a condition in which your body makes very little or no urine). This is because hydrochlorothiazide works by clearing excess salt and water from your body through your urine. If your body cannot produce urine, hydrochlorothiazide may not work properly. In some cases, factors or conditions could prevent your doctor from prescribing hydrochlorothiazide due to the risk of harm.
Cyclobenzaprine may enhance the effects of alcohol, barbiturates, and other CNS depressants. Tricyclic antidepressants have been reported to produce arrhythmias, sinus tachycardia, prolongation of the conduction time leading to myocardial infarction and stroke. Acute recovery phase of myocardial infarction, and patients with arrhythmias, heart block or conduction cyclobenzaprine interactions with alcohol disturbances, or congestive heart failure.
Calls to our general hotline may be answered by private treatment providers. We may be paid a fee for marketing or advertising by organizations that can assist with treating people with substance use disorders. Continuing dry mouth can increase the likelihood of dental disease, including gum disease, tooth decay and fungal infections.
Flexeril and alcohol are both central nervous system (CNS) depressants, with each of them having its own effective means of relaxing or easing the pain. However, mixing them and using them together would be unwise and may lead to dangerous and devastating effects. Cyclobenzaprine warnings, comprising the effects of using each of these medications on their own include a slowing of the mental faculties, drowsiness, lightheadedness, and lowered motor coordination. When used together, these effects may be exacerbated, increasing the risk of an accident. There is also a case where the combination of a high concentration of Cyclobenzaprine and alcohol proved to be fatal. Lastly, combining and using the two together results in a far higher risk and the likelihood of any related side effects as well as a physiological or physical dependency and Cyclobenzaprine abuse.
There are, however, no adequate and well-controlled studies in pregnant women. Because animal reproduction studies are not always predictive of human response, this drug should be used during pregnancy only if clearly needed. Eight double-blind controlled clinical studies were performed in 642 patients comparing cyclobenzaprine hydrochloride 10 mg, diazepam, and placebo.
Unless carefully evaluated and advised by a health professional, one should not mix and use Cyclobenzaprine and Tramadol together. Some drugs can interact with this drug and increase the risk of side effects. Mixing addictive muscle relaxants with alcohol can cause serious side effects.
The medicine may also be prescribed to treat back or neck pain, usually for only two to three weeks. Cyclobenzaprine, a muscle relaxant, blocks nerve impulses sent to the brain. Doctors use it with rest and physical therapy to treat skeletal muscle pain or injury. Doctors often use it with rest and physical therapy to treat skeletal muscle conditions like pain or injury..
At the very least, you should wait around 8 hours after taking a dose as that is the timeframe where the drug has the most effect. The reported half-life of the drug, the amount of time that it takes for your body to metabolize half of the medication and remove it from your body, ranges between 8-37 hours in most adults. Inpatient treatment is your best choice if you have other medical conditions that need to be treated, lack a healthy and strong home environment, or need a highly-structured and intensive program. Muscle relaxers like cyclobenzaprine usually last around four to six hours. Cyclobenzaprine has a half-life that ranges between eight to 37 hours for most adults. The half-life of a substance is the amount of time it takes for your body to metabolize half of the medication and remove it from your body.
These supplements are believed to help prevent heart disease and support brain and eye health. As a result, combining them with hydrochlorothiazide may increase your risk of low blood pressure. Although rare, deaths may occur from overdosage with cyclobenzaprine.
Cyclobenzaprine can become habit-forming if not taken as directed, but when it is combined with alcohol, addiction is more likely. Addiction, a chronic, relapsing brain disease, is referred to as substance addiction. When cyclobenzaprine is used with alcohol, it is referred to as polydrug use. Another reason why cyclobenzaprine and alcohol are a dangerous combination? Both substances are processed by the liver, which is already in danger of becoming overwhelmed by alcohol alone.
Multiple drug ingestion (including alcohol) is common in deliberate cyclobenzaprine overdose. As management of overdose is complex and changing, it is recommended that the physician contact a poison control center for current information on treatment. Signs and symptoms of toxicity may develop rapidly after cyclobenzaprine overdose; therefore, hospital monitoring is required as soon as possible. The acute oral LD 50of cyclobenzaprine is approximately 338 and 425 mg/kg in mice and rats, respectively.
Skeletal muscle relaxants (see Table 1) work primarily in the spinal cord and brain, also called the central nervous system, to block pain sensations between the nerves and the brain. They relieve painful muscle spasms and spasticity due to conditions like acute back pain or multiple sclerosis. Chemical dependence occurs when you stop taking the drug and/or alcohol abruptly and experience withdrawal symptoms. The National Institute on Drug Abuse (NIDA) notes that dependence can happen with chronic use of any drug, even when they are taken as prescribed. Dependence does not necessarily mean you are addicted to cyclobenzaprine and/or alcohol. However, the more these two substances are abused, the more likely you will become addicted to them.
Be sure to inform them of your prescription medications, as well as over-the-counter (OTC), vitamin and herbal or dietary products that you use. If you must have an alcoholic beverage, it is best to wait 24 hours or longer after taking your last dose of the muscle relaxer to avoid any potentially harmful effects. By Ayesha Gulzar, PharmDAyesha Gulzar is a clinical pharmacist interested in medical research, pharmacy practice, and medication therapy management. Dr. Gulzar has been working in medical communications, writing medical and clinical research for patients and health professionals in the United Kingdom.
To learn whether hydrochlorothiazide interacts with supplements, herbs, or vitamins, see the “Hydrochlorothiazide and other interactions” section. This article will focus on interactions for the oral tablet form of hydrochlorothiazide. Cyclobenzaprine hydrochloride relieves skeletal muscle spasm of local origin without interfering with muscle function. It is ineffective in muscle spasm due to central nervous system disease.